I. Cov ntaub ntawv yooj yim
Lub npe: Semaglutide
Hom: GLP-1 receptor agonist (ntev-ua yeeb yam glucagon-zoo li peptide-1 analog)
Kev Tswj Xyuas Txheej Txheem: Kev txhaj tshuaj subcutaneous (ib zaug ib lim piam)
II. Indications thiab Domestic Approval Status
Pom zoo Indications
Kev Kho Mob Ntshav Qab Zib Hom 2 (Kev Pom Zoo los ntawm NMPA):
Cov koob tshuaj: 0.5 mg lossis 1.0 mg, ib zaug ib lim tiam.
Kev Ua: Tswj cov ntshav qabzib thiab txo qis kev pheej hmoo ntawm cov hlab plawv.
Kev Noj Qab Haus Huv / Kev Noj Qab Haus Huv
III. Mechanism of Action thiab Efficacy
Core Mechanism: Activates GLP-1 receptors, ncua lub plab zom mov, thiab ua rau kom satiety.
Ua rau ntawm qhov chaw hypothalamic qab los noj mov, inhibiting qab los noj mov.
Txhim kho insulin rhiab heev thiab tswj cov metabolism.
Poob Qhov Ua Tau Zoo (raws li kev sim tshuaj ntsuam xyuas thoob ntiaj teb):
Qhov hnyav poob qis tshaj 68 lub lis piam: 15% -20% (ua ke nrog kev ua neej nyob).
Cov neeg mob uas tsis muaj ntshav qab zib (BMI ≥ 30 lossis ≥ 27 nrog cov teeb meem):
Cov neeg mob ntshav qab zib: Cov nyhuv poob qis me ntsis (kwv yees li 5% -10%).
IV. Muaj pes tsawg leeg thiab contraindications
Muaj pes tsawg leeg
International Standards (saib rau WHO):
BMI ≥ 30 (obese);
BMI ≥ 27 nrog ntshav siab, ntshav qab zib, lossis lwm yam kab mob metabolic (hnyav).
Kev xyaum hauv tsev: Yuav tsum muaj kev tshuaj xyuas tus kws kho mob; tam sim no tsuas yog siv rau kev tswj qhov hnyav hauv cov neeg mob ntshav qab zib.
Contraindications
Tus kheej lossis tsev neeg keeb kwm ntawm medullary thyroid carcinoma (MTC);
Ntau yam endocrine neoplasia syndrome hom 2 (MEN2);
Cov poj niam cev xeeb tub los yog lactating;
Cov kab mob loj hauv plab (xws li keeb kwm ntawm pancreatitis).
V. Cov Kev Phem thiab Kev Phem
Cov kev mob tshwm sim tshwm sim (qhov tshwm sim> 10%):
xeev siab, ntuav, raws plab, cem quav (txo nrog kev siv ntev).
Txo qab los noj mov, qaug zog.
Kev pheej hmoo loj:
Thyroid C-cell qog (kev pheej hmoo pom nyob rau hauv cov kev tshawb fawb tsiaj, tseem tsis tau meej meej nyob rau hauv tib neeg);
Pancreatitis, kab mob gallbladder;
Hypoglycemia (yuav tsum ceev faj thaum siv nrog lwm cov tshuaj hypoglycemic).
VI. Kev siv tam sim no hauv Suav teb
Txoj Kev Tau Txais:
Kev Kho Mob Ntshav Qab Zib: Tshuaj los ntawm lub tsev kho mob tsis tu ncua.
Kev kho qhov hnyav: Yuav tsum tau soj ntsuam nruj los ntawm kws kho mob; Qee lub tsev kho mob tertiary 'endocrinology departments tuaj yeem sau npe rau nws.
Kev pheej hmoo los ntawm Kev Tsis Ncaj Ncees: Cov tshuaj yuav los ntawm cov kev tsis raug cai yuav raug cuav lossis khaws cia tsis raug, ua rau muaj kev pheej hmoo ntawm kev nyab xeeb.
VII. Cov lus pom zoo siv
Ua raws li tus kws kho mob cov ntawv sau nruj me ntsis: Siv tsuas yog tom qab kws kho mob soj ntsuam cov ntsuas metabolic thiab tsev neeg keeb kwm kho mob.
Combined Lifestyle Intervention: Cov tshuaj yuav tsum tau ua ke nrog kev tswj kev noj haus thiab kev tawm dag zog kom ua tiav cov txiaj ntsig zoo.
Kev Saib Xyuas Lub Sij Hawm Ntev: Tsis tu ncua xyuas cov thyroid ua haujlwm, pancreatic enzymes, thiab lub siab thiab lub raum ua haujlwm.
Post lub sij hawm: Nov-03-2025