Cov txiaj ntsig ntawm txoj kev tshawb fawb tau pom tias cov txiv neej uas tau txais kev txhaj tshuaj testosterone undecanoate ntev tau ua raws li kev kho mob tom qab 1 xyoos ntau dua li cov txiv neej uas tau txais kev txhaj tshuaj luv luv testosterone propionate.
Kev soj ntsuam rov qab los ntawm cov ntaub ntawv los ntawm ntau dua 122,000 tus txiv neej hauv Tebchaws Meskas tau pom tias cov txiv neej kho nrog testosterone undecanoate (Aveed, Endo Pharmaceuticals) muaj qhov zoo sib xws hauv thawj 6 lub hlis ntawm kev kho mob raws li cov txiv neej kho nrog testosterone cypionate.Adherence tus nqi sib txawv ntawm 7 mus rau 12 lub hlis, tsuas yog 8.2% ntawm cov neeg mob kho nrog testosterone cypionate txuas ntxiv kev kho mob rau 12 lub hlis piv rau 41.9% ntawm cov neeg mob kho nrog testosterone undecanoate.
"Cov ntaub ntawv pov thawj qhia tias hom kev kho mob testosterone yooj yim dua, xws li kev txhaj tshuaj ntev ntev, yog qhov tseem ceeb rau kev txaus siab ntawm cov txiv neej uas muaj testosterone tsis txaus los kho ntxiv," said Abraham Morgenthaler, MD, tus pab xibfwb ntawm kev phais.Helio hais tias nws tau ua haujlwm hauv chav kho mob urology ntawm Beth Israel Deaconess Medical Center ntawm Harvard Medical School."Muaj kev lees paub txog cov tsos mob ntawm lub testosterone thiab muaj rog ntau dua li kev kho ntshav qab zib tsis yog ib qho kev kho mob ntau ntxiv rau kev kho mob ntshav qab zib, tsis muaj cov nqaij tawv muaj zog ntxiv rau kev kho ntshav qab zib, tsis muaj cov leeg ntshav ntxiv .ntshav ntshav.Txawm li cas los xij, cov txiaj ntsig no tsuas yog pom tau yog tias cov txiv neej ua raws li kev kho mob. "
Morgenthaler thiab cov npoj yaig tau ua qhov kev tshawb fawb rov qab los ntawm cov ntaub ntawv los ntawm Veradigm database, uas muaj cov ntaub ntawv kho mob hauv hluav taws xob los ntawm US cov chaw kho mob sab nraud, suav nrog cov uas pib txhaj tshuaj testosterone undecanoate lossis testosterone cypionate ntawm 2014 thiab 2018. Cov txiv neej hnub nyoog 18 xyoo thiab tshaj.Cov ntaub ntawv khaws cia nyob rau hauv 6-lub hlis increments raws li lub Xya hli ntuj 2019. Kev kho kev kho yog txhais raws li ib tug ncua sij hawm ntawm kev teem sij hawm uas tsis pub tshaj ob zaug qhov pom zoo noj ncua sij hawm ntawm 20 lub lis piam rau testosterone undecanoate los yog 4 lub lis piam rau testosterone cypionate.Kev ua raws li kev kho mob tau raug soj ntsuam txij hnub thawj zaug txhaj tshuaj mus txog rau hnub txiav tawm, hloov tshuaj, lossis xaus rau qhov kev kho mob testosterone thawj zaug.Testosterone tsis ua raws li pawg Testosterone undecanoate tau txhais tias yog qhov sib txawv ntawm ntau tshaj 42 hnub ntawm hnub kawg ntawm thawj zaug thiab hnub pib ntawm lub sijhawm teem thib ob, lossis qhov sib txawv ntawm ntau tshaj 105 hnub ntawm kev teem sijhawm yav tom ntej.Kev tsis sib haum xeeb hauv pawg testosterone cypionate tau txhais tias yog lub sijhawm ntawm ntau dua 21 hnub ntawm qhov kawg ntawm ib lub sijhawm teem sijhawm thiab pib ntawm qhov txuas ntxiv.Cov kws tshawb fawb tau soj ntsuam cov kev hloov pauv hauv lub cev hnyav, BMI, ntshav siab, qib testosterone, tus nqi ntawm cov kab mob plawv tshiab, thiab muaj feem cuam tshuam los ntawm 3 lub hlis ua ntej txhaj tshuaj thawj zaug rau 12 lub hlis tom qab pib kho.
Pawg kawm muaj 948 tus txiv neej noj testosterone undecanoate thiab 121,852 txiv neej noj testosterone cypionate.Ntawm qhov pib, 18.9% ntawm cov txiv neej hauv pawg testosterone undecanoate thiab 41.2% ntawm cov txiv neej hauv pawg testosterone cypionate tsis muaj kev kuaj mob ntawm hypogonadism.Txhais tau tias dawb Testosterone nyob rau hauv lub hauv paus yog siab dua nyob rau hauv cov neeg mob noj testosterone undecanoate piv rau cov neeg noj testosterone cypionate (65.2 pg / mL vs 38.8 pg / mL; P < 0.001).
Nyob rau thawj 6 lub hlis, kev ua raws li kev coj ua zoo sib xws hauv ob pawg.Nyob rau lub sijhawm ntawm 7 mus rau 12 lub hlis, pawg testosterone undecanoate muaj qhov ua tau zoo dua li pawg testosterone cypionate (82% vs 40.8%; P < 0.001).Piv rau 12 lub hlis, qhov feem ntau ntawm cov txiv neej nyob rau hauv pawg testosterone undecanoate txuas ntxiv naive testosterone therapy (41.9% vs 0.89.9%; P < 0.001).Cov txiv neej noj testosterone cypionate.
Morgenthaler tau hais tias "Qhov xav tsis thoob, tsuas yog 8.2 feem pua ntawm cov txiv neej uas txhaj tshuaj testosterone cypionate txuas ntxiv kho tom qab 1 xyoos," Morgenthaler tau hais."Tus nqi qis heev ntawm kev siv tshuaj testosterone feem ntau hauv Tebchaws Meskas txhais tau hais tias cov txiv neej tsis muaj testosterone raug kho tsis zoo."
Cov neeg mob kho nrog testosterone undecanoate muaj ntau qhov kev hloov pauv hauv tag nrho cov testosterone (171.7 ng / dl vs 59.6 ng / dl; P < 0.001) thiab dawb testosterone (25.4 pg / ml vs 3.7 pg / ml; P = 0.001).Kev nce ntawm 12 lub hlis piv nrog cov neeg mob kho nrog testosterone cypionate.Testosterone undecanoate pom qhov sib txawv tsawg dua hauv tag nrho cov qib testosterone ntau dua li testosterone cypionate.
Thaum 12 lub hlis, kev hloov pauv hauv qhov hnyav, BMI, thiab ntshav siab tau zoo sib xws ntawm pawg.Cov pawg testosterone undecanoate muaj ntau dua ntawm cov txiv neej uas tau kuaj pom erectile kawg thiab rog ntawm kev rov qab los, thaum pawg testosterone cypionate muaj ntau dua cov txiv neej kuaj pom tias muaj ntshav siab, mob plawv tsis ua haujlwm, thiab mob ntev.
Kev tshawb fawb ntxiv yog xav tau kom nkag siab tias vim li cas cov txiv neej feem ntau txhaj tshuaj testosterone cypionate nres kev kho mob hauv ib xyoos, Morgenthaler hais.
"Peb tuaj yeem xav tias hauv txoj kev tshawb no, testosterone undecanoate tau siv ntau dua rau 12 lub hlis vim qhov yooj yim ntawm cov tshuaj ua haujlwm ntev, tab sis saib seb qhov no tuaj yeem yog vim lwm yam (xws li tus nqi), aversion rau Kev txhaj tshuaj tiv thaiv tus kheej tsis tu ncua, tsis muaj kev txhim kho tseem ceeb hauv cov tsos mob, lossis lwm yam laj thawj, "Morgenthaler tau hais.
Post lub sij hawm: Jul-05-2023